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Published clinical-trial data and ongoing studies continue to evaluate its safety profile, including gastrointestinal tolerability, heart-rate changes, pancreatic and gallbladder-related events, kidney-related risks in the setting of dehydration, and other potential adverse events

While the brain does produce GLP-1, most circulating GLP-1 is gut-derived [110,111]

At the time, there were no differentiated GLP-1secreting enteroendocrine cell lines suitable for studies of intestinal proglucagon gene expression

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Your doctor may recommend adjustments to your treatment plan, referral to a specialist (endocrinologist, urologist, gynecologist, or sexual health counselor), or additional interventions to address underlying causes