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Your body adapts to the medication's appetite-suppression effects (a process called tachyphylaxis), and your metabolic baseline resets to a new, lower set point

(4) clinical trials evaluating MSTN inhibition for the treatment of metabolic disorders

Avoid stimulant laxatives like senna or bisacodyl initially, as they can cause cramping and may lead to rebound constipation with prolonged use
Italian Journal of Pediatrics
