ly3437943 retatrutide triple agonist glp-1 gip glucagon (LY3437943): Mechanism of Action and Research Overview Tempted by retatrutide? You're not

GLP-1s like Wegovy and Mounjaro have four mechanisms to improve blood sugar levels and support weight loss: Improve insulin function: Improving insulin response to glucose from meals enables the body to move glucose from the blood and into the cells (like muscle cells) to be burnt for energy or stored as glycogen

As individuals are losing fat, they are also rapidly losing precious muscle tissue

Improved blood sugar control (slower glucose spikes)

Zepbound produces higher average weight loss based on clinical trial data

Further, some PCPs worry about lack of reimbursement for time spent discussing obesity, but obesity codes are often now reimbursed