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In other words, they have very high standards to keep

These agents vary in receptor affinity, duration of action, molecular size, and ability to cross biological barriers, which likely translates to different efficacy profiles in the eye

MEDI0832 (now known as cotadutide) is a balanced co-agonist based on the peptide sequence of glucagon, modified at specific amino acid positions in addition to a palmitic fatty acid side chain to prolong activity
