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Indications: Type 2 Diabetes Mellitus (monotherapy or add-on therapy) Especially useful in patients who cannot tolerate metformin or sulfonylureas Can be used in elderly and patients with mild renal impairment Approved Agents in India: Sitagliptin (Januvia) Vildagliptin (Galvus) Saxagliptin (Onglyza) Linagliptin (Trajenta) No renal dose adjustment needed Alogliptin (Nesina) Dosing: Once daily oral dosing Some agents require renal dose adjustment (except Linagliptin) Often combined with metformin or SGLT2 inhibitors Side Effects: Nasopharyngitis, headache GI upset (mild) Rare: Acute pancreatitis, severe joint pain, skin reactions Saxagliptin may slightly increase risk of heart failure in some patients Advantages Over Other Classes: Weight neutral Low risk of hypoglycemia Well tolerated in the elderly Convenient once-daily dosing Limitations: Modest HbA1c reduction (0.50.8%) Not effective in Type 1 Diabetes Less potent than GLP-1 analogs or SGLT2 inhibitors Conclusion: DPP-4 inhibitors are a safe, effective, and well-tolerated option for many patients with T2DM especially those needing an add-on to metformin or who can't tolerate injectables

Allure Medical brings our revolutionary GLP-1 Agonist injections for weight loss to Charlotte, NC

Hair loss has not been reported as an adverse event in any of the phase 2 tr...

Learn how Brandon, Trinity, and Westchase, FL, patients safely can administer Semaglutide and Tirzepatide for long term weight loss.

As a result, Rybelsus is now the first and only oral glucagon-like peptide 1 receptor agonist (GLP-1 RA) mimicking a natural hormone in your body that helps regulate blood sugar, appetite, and digestion available in the EU for type 2 diabetes with a proven cardiovas