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People with existing disorders may suffer more Some people may tend to go overboard on the restrictive eating, depriving their body of nourishment and the required calories

Systemic inflammation driven by steatosis and necro-inflammatory changes in MASLD activates pathways such as toll-like receptors (TLR) and Nuclear Factor-kappa B (NF-B), causing cardiac and vascular tissue damage

Cause Deficiency of Alpha-L-iduronidase Leads to accumulation of dermatan sulfate and heparan sulfate in body tissues Inherited as autosomal recessive 2

doi:10.1016/j.schres.2007.01.003
