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Nausea, which is common in the first weeks, can lead to reduced fluid intake
in HFpEF, the prevalence of obesity reaches up to 80%
Should retatrutide complete its clinical development programme and receive regulatory approval, NICE would conduct a formal technology appraisal before it could be recommended within NHS care pathways

Tesofensine and sibutramine were found to be most effective in reducing fat deposits, particularly in the abdomen and under the skin, and this was accompanied by lower levels of fat in the blood