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N = 2 biological replicates for c , d , (representative data) and N = 1 for h , and i

This approach reflects lessons learned from earlier GLP-1 receptor agonists, where gastrointestinal side effects often limited compliance if higher doses were given immediately

Given the high baseline depression incidence (14.8% annually), this translated to an absolute risk difference of 2.2% and a number needed to harm of 45 over 1 year

in: PubMed | Google Scholar | 1 Ted Rogers Centre for Heart Research, University of Toronto, Toronto, Ontario, Canada