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Recent evidence suggests that Westernized lifestyles, including dietary habits and sedentary behavior, could have contributed to the increasing global prevalence of IBD, particularly in newly industrialized countries ( GLP-1 receptor agonists (GLP-1 RAs) have gained attention due to their numerous effects on gut metabolism and immune regulation

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Many factors are involved and play a substantial role in the development of DN, which include metabolic alterations, hemodynamic disorders, and dysregulation of hormone pathways, most especially angiotensin II, which itself, contributes to renal injury via oxidative stress [4]

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