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The BMI requirements for GLP-1 medications article breaks down the specific thresholds and explains how comorbidities affect eligibility

He points to a clinical trial published in The New England Journal of Medicine studying the impact of semaglutide in people who were diagnosed with both overweight or obesity and heart disease, but who had no history of diabetes

These factors highlight the importance of careful monitoring when combining oral contraceptives with GLP-1 therapy

Safety and Tolerability Profile The safety profile of tirzepatide across clinical trials has been generally consistent with other incretin-based therapies

These are due to finish in May 2026