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the first scopolamine transdermal patch was approved by the FDA in 1979 ( stratum corneum (Figure 1), a layer of 1020 m of death tissue which restricts the permeability of most of the hydrophobic and hydrophilic drugs ( FIGURE 1 MP are an advanced strategy for the safe, painless, easy, and efficient delivery of drugs across the stratum corneum to reach the dermis layer ( There are several revisions about MP approaches focusing mainly on microneedle materials, microfabrication methods, delivery strategies, and biomedical applications ( 2 Targeted transdermal drug delivery TDDS, including MP, provide a controlled delivery system with prolonged administration and a sustained effect of drugs

Many people experience constipation early in treatment