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Introduction Diabetic kidney disease (DKD) is a global concern because it causes end stage renal disease (ESRD) and affects mortality in diabetic patients

Since GLP-1 patches arent FDA approved, theres no guarantee of quality or consistency, and they havent been tested in clinical trials, so theres no long-term safety data

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Insulin, the natural ligand of the IR, binds to its extracellular domain, triggering insulin signaling and activating downstream pathways

Any purported benefits remain speculative and require rigorous clinical investigation before recommendations can be made