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Guidelines: 2021 ESC Cardiovascular Prevention Question #6 with Dr
Semaglutide directly activates GLP-1 receptors to blunt appetite and slow gastric emptying

Mechanisms include appetite suppression, higher resting metabolic rate, fewer food cravings, and a mild thermogenic effect

Together, these results indicate that body composition changes on semaglutide may enhance CV benefits of the drug among overweight or obese patients, but they do not fully account for effects on MACE risk reduction, especially early in the course of treatment

What the start of treatment usually looks like Clinicians typically begin low and increase gradually
