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By virtue of the time delay in the neuroendocrine process and the intracellular/genomic actions of glucocorticoids, the HPA axis response occurs at longer latency than the sympathoadrenal response, and has more temporally extended cellular action

So why wouldnt we just use medications to increase GLP-1 production

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Potential vision problems that may be linked to Rybelsus: Nonarteritic Anterior Ischemic Optic Neuropathy (NAION): One of the most concerning conditions that may be linked to Rybelsus use includes NAION