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These compounds have similar amino acid sequences compared to endogenous GLP-1, with small alterations, a free fatty acid side chain that binds to albumin, explicitly seen in liraglutide and semaglutide, that alter their pharmacokinetic properties (e.g., increased half-life and duration of action) [3]

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Over the three-week study, patients on liraglutide experienced a 40% reduction in opioid cravings, with this effect evident even at the lowest dose

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This requires carefully designed clinical trials that account for commercial dynamics, as well as pre-launch disease education to prime market understanding regarding where new therapies fit in the treatment paradigm
