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In another study, liraglutide was shown to prevent the onset of endoplasmic reticulum stress in HUVECs exposed to high glucose via dose dependent induction of mitochondrial fusion marker, OPA1, thereby inhibiting mitochondrial fragmentation and apoptosis [104]

The evidence doesnt confirm most severe risks, but careful monitoring and patient education are essential to maximize benefit and minimize harm

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alternatively, if a one-hour wait on an empty stomach is not feasible, then levothyroxine can be taken at bedtime, maintaining as great a time gap as possible post-dinner