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GLP-1 receptor activation primarily promotes glucose utilization and glycogen storage while reducing hepatic glucose production

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The primary cause for alarm is thyroid C-cell hyperplasia, which has been the subject of FDA boxed warnings since a research conducted on rats showing dose-dependent C-cell tumors (Madsen et al

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DPP-IV modulates diverse cellular processes including survival, proliferation, and differentiation, and thereby enhances or diminishes tumorigenesis depending on the types or phases of tumors (Havre et al., 2008)