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In addition to the gut, GLP-1 is produced within the brain, specifically in neurons located in the nucleus of the solitary tract (NTS)

United European Gastroenterol J

Managing Side Effects During Semaglutide Dose Increases Nausea and appetite loss during dose escalation are expected physiological responsesyour brain's satiety centers and gastric motility are adapting to GLP-1 signaling

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GO term enrichment further highlighted significant terms related to epidermal development, tissue morphogenesis, and cytokine binding within the biological process and molecular function categories (Fig