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Although the higher dose showed modest within-group weight reduction and improved HbA1c, unexpectedly substantial placebo-associated weight loss limited the observed treatment effect.

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The rising prevalence, alongside obesity and type 2 diabetes, underscores the need for early risk stratification and integrated therapeutic strategies

Akkermansia muciniphila produces P9, a small protein that interacts with ICAM-2 to increase thermogenesis and glucagon-like peptide-1 (GLP-1) secretion in mice

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