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Description
An active-comparator new user study design was used to minimise risks of confounding and time related biases from using real world studies of drug effects

The tradeoff: retatrutide appeared to show higher rates of nausea (42.4%), diarrhea (32.0%), and vomiting (25.3%) than tirzepatide or orforglipron at their top doses

The number of therapeutic options is limited and are often associated with adverse side effects
Dual-Action Support for Your Gut

The botanical product kratom produces opioid-like effects at high doses and is sometimes used for opioid replacement by individuals with opioid use disorder