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The role of GLP-1 in the regulation of the stress axis seems to be undeniable

Key considerations for determining appropriate calorie intake include: Basal metabolic rate : The minimum energy required for basic physiological functions Physical activity level : More active individuals require higher calorie intake Weight loss goals : Gradual loss of 0.51 kg per week is generally recommended Nutritional adequacy : Sufficient calories to meet protein, vitamin, and mineral requirements Medical comorbidities : Conditions such as chronic kidney disease may require modified nutritional approaches Patients should be encouraged to focus on nutrient density rather than simply calorie quantity, prioritising foods that provide essential nutrients within their reduced intake capacity

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Reasons for this heterogeneity in response to pharmacotherapy are poorly understood

Weight loss from GLP-1 therapy improves insulin sensitivity, which may reduce bloating or other hormonal side effects, but the contraceptive dose typically stays the same