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Like the central nervous system, the enteric nervous system consists of a range of neuronal cell types expressing different neurotransmitters and receptors, whose precise interrelationships remain unclear (Galligan, 2002)

While the mechanism underlying the diminished insulin response to GIP in T2D has not yet been fully elucidated, receptor downregulation (55) and desensitization (56) have been suggested as potential causes

Studies have also explored its impact on oxidative stress and inflammation in various biological models

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