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NICE recommends these agents particularly for patients with established cardiovascular disease, heart failure, or chronic kidney disease

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Agents such as Survodutide and Mazdutide, which coactivate GLP1 and glucagon receptors, harness this pathway to achieve substantial weight reduction, with glucagondriven thermogenesis and energy expenditure being central to their efficacy [23, 32, 33]

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One large observational study of 461,382 patients taking GLP-1 medications found that 15.1% developed vitamin deficiencies over 12 months, including 13.6% with vitamin D deficiency, 0.0% with niacin deficiency, and 0.1% with thiamine deficiency