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Patients should follow the specific instructions provided with their tirzepatide pre-filled pen, which include: Cleanse the injection site thoroughly with an alcohol wipe and allow the skin to dry completely before injecting, as residual alcohol can cause stinging and irritation Follow the pen instructions exactly, including holding the pen against the skin until the second click is heard and the indicator shows the dose is complete Hold the pen against the skin for the time specified in the instructions after the second click before removing it from the skin Avoid injecting into areas with scars, bruises, moles, or skin abnormalities, as these sites are more prone to irritation Site rotation is paramount: patients should maintain a written or digital log of injection sites to ensure systematic rotation and avoid repeated use of the same area within a short timeframe

Protein-first, with fiber as a first-class goal

This extended activity means the appetite control and fullness signals continue working between meals and throughout the week

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liraglutide at low doses alone, did not demonstrate the greater efficacy of the combination therapy, as the area of VAT was reduced in all the three treatments arms without inter-groups differences [59, 60]