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10-13 In subsequent trials where higher doses of the GLP-1/GIP agonists were used in non-diabetic obese subjects, weight loss of 15% to 21% of body weight was seen

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Compounded semaglutide must be prepared under sterile conditions using pharmaceutical-grade raw materials, and every vial is tested for sterility, potency, and safety before shipment to patients

Some patients report that night-time dosing allows them to sleep through initial side effects, though there is no conclusive clinical evidence that timing categorically reduces nausea