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This results in a lower ability to promote receptor internalization compared with endogenous GLP-1, so it allows to have an increased GLP-1R expression on the cell surface, which translates in more robust insulinotropic properties, possibly explaining the enhanced insulin secretion (in both diabetic and not diabetic human islets), induced by TZP ( Figure 1 )
Patients must be obese or have health issues related to excess weight

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It also comes from -cells in the pancreatic islet and neurons in the nucleus of the solitary tract (18)
