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Both ligands had similar cAMP potency but the exendin-4-C16 showed 2.5-fold bias towards G protein recruitment and a 60% reduction in -arrestin-2 recruitment efficacy compared to exendin-4, as well as reduced GLP-1R endocytosis and preferential targeting towards recycling pathways

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Here, we provide a comprehensive review of the therapeutic potential of incretin mimetics and insulin in AD and PD.

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Novo's Wegovy pill already has over 600,000 prescriptions since it was approved in December, and Foundayo doesn't require fasting which is a major differentiator