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Hyman, and other doctors who actually work with patients on peptides

GLP-1RAs and related incretin-based therapies contribute to sustained weight loss in obese individuals, which is accompanied by improvements in related comorbidities

The dosing schedule used in clinical trialsevery seven dayswas carefully chosen to balance efficacy with tolerability

The study highlights emerging treatments aiming to separate GCs anti-inflammatory and metabolic actions, including selective glucocorticoid receptor ligands and 11beta-hydroxysteroid dehydrogenase type 1 inhibitors

Conclusion Mazdutide and tirzepatide represent significant advancements in obesity and type 2 diabetes management, leveraging GLP-1-based mechanisms to achieve weight loss and glycaemic control