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Anecdotally, I have heard him say that he has to go as far as recommending protein supplementation2 to patients who are clearly not eating more than 500 calories a day, simply because they do not have the appetite to.3 Patients who, before they were on these drugs, consumed upwards of 5000 calories a day

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This short half-life made therapeutic use challenging for decades, until researchers began developing GIP receptor agonists and dual/triple agonists that could resist degradation or mimic its effects more efficiently

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