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excreted unchanged by kidneys Half-life: ~12 hours Excretion: Renal Clinical Uses Hypertension first-line therapy Heart failure reduces morbidity and mortality Post-myocardial infarction improves survival Diabetic nephropathy slows progression of kidney damage Proteinuric chronic kidney disease Adverse Effects Cough: Dry, persistent (due to bradykinin) Hyperkalemia: aldosterone potassium retention Hypotension: Especially in volume-depleted patients Angioedema: Rare but serious (swelling of lips, tongue, airway) Renal dysfunction: creatinine, especially in bilateral renal artery stenosis Contraindications Pregnancy: Teratogenic (avoid in 2nd/3rd trimester) Bilateral renal artery stenosis risk of acute kidney injury History of angioedema with ACE inhibitors Drug Interactions Potassium-sparing diuretics / K supplements: risk of hyperkalemia NSAIDs: May reduce antihypertensive effect, risk of renal injury Other antihypertensives: Additive hypotensive effect Class: ACE inhibitor Mechanism: angiotensin II, aldosterone, bradykinin BP Major adverse effects: Cough, hyperkalemia, hypotension, angioedema Uses: Hypertension, heart failure, diabetic nephropathy Mnemonic for ACE Inhibitor Side Effects: CAPTOP C Cough A Angioedema P Potassium (hyperkalemia) T Teratogenic O Orthostatic hypotension P Proteinuria / renal impairment To view or add a comment, sign in More Relevant Posts Atorvastatin Atorvastatin is a HMG-CoA reductase inhibitor (statin) used to lower cholesterol and prevent cardiovascular disease

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Patients should not attempt to obtain or use this medication outside of a regulated clinical trial setting

Indias GLP-1 market was valued at $150.8 million in 2025 and is projected to reach $1 billion by 2033

People who lose weight together often have better results and more consistent habits