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For GLP-1 analogs, meta-analyses have shown that women tend to experience greater weight loss than men, with a mean difference of approximately 1 kg, potentially due to sex-specific differences in GLP-1 receptor expression and hormonal interactions.[55] This more favorable response in women may also be attributable to interactions between estrogen and GLP-1, as demonstrated by preclinical studies in mice.[56,57] Regarding MSTN inhibition, sex-based variation has been reported in both circulating MSTN levels and physiological responses

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Drucker DJ, Buse JB, Taylor K, Kendall DM, Trautmann M, Zhuang DL, et al

Probably due to the lack of complementary interacting residues, superimposing GIP or GLP-1 to GCG bound to GCGR shows that the aligned peptides reduced favorable contacts with GCGR compared to GCG by removing one hydrogen bond (Y10 P (GCG)/Y10 P (GIP)/V16 P (GLP-1)-Q142 1.40b (GCGR)) and pi-pi stacking (Y13 P (GCG)/A13 P (GIP)/Y19 P (GLP-1)-Y138 1.36b (GCGR)) and by repulsing the interaction between Y1 P (GIP) and I235 3.40b (GCGR)