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Genetics play a surprisingly large roleyour FTO gene variant, for instance, affects how your body regulates energy balance and may explain why one person loses eight pounds monthly while another loses four

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There also have been no clinical trials to see if Rybelsus is safe or effective for people under the age of 18 (Novo Nordisk, 2021)

Martins et al., in experiments in obese mice, showed changes in anorexigenic hormones with POMC/MC4R lessened activation and orexigenic NPY/AgRP increased activation, accompanied by leptin resistance and increased Socs3 gene expression, blocking the central action of leptin [131]

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