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Description
This dual effectmedication-driven metabolic shift plus weight-loss-related insulation lossexplains why cold sensitivity often emerges during the first weeks of treatment when weight loss accelerates
71 Besides, some SGLTs in CNS have been shown to act as glucose sensors, by counter-regulating hypoglycemia
The dual mechanism is why Eli Lilly positions tirzepatide as a distinct therapeutic option and why some patients specifically need it rather than a single-agonist alternative
C.LicinioJ
doi:10.1016/j.molmet.2018.05.014 52
