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HGP is decreased in Dpp4 hep/ mice but not mice with deletion of Dpp4 from Tie2 + endothelial cells via GLP-1 and GIP-dependent pathways

"Some can maintain on a lower dose, while others require ongoing therapy at their current dose." If you're like me and squeamish about the prospect of weekly injections indefinitely, take note that oral GLP-1s are now on the market: the Food and Drug Administration (FDA) approved oral Wegovy in December 2025 and Foundayo (orforglipron) in April 2026

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We do not have a big, randomized control trial with these newer medications in couples with unexplained infertility. Finkle has also observed improved ovulation among women with PCOS prescribed GLP-1 therapy who have lost 5% to 10% of their initial body weight