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patients had CKD stages 1 to 5 diagnosed by Kidney Disease: Improving Global Outcomes guidelines plus at least 3 months of one of the following: moderate to severe albuminuria regardless of estimated glomerular filtration rate (eGFR), eGFR less than 90 mL/min/1.73 m2 with structural abnormalities of the kidney or urinary sediment abnormalities, or eGFR less than 60 mL/min/1.73 m2

*Compared to Magnesium Oxide.

It provides endothelial surface area for substrate exchange between the plasma compartment and the muscle interstitium

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Clearance and the total volume of distribution were approximately proportional to body weight