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The practical impact of metabolic withdrawal: large-scale population studies suggest that individuals who use and then discontinue GLP-1RAs before pregnancy may experience excessive gestational weight gain (GWG) and an increased risk of gestational diabetes mellitus (GDM) and gestational hypertension (137)

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Together these data suggest a role for -cell GLP-1 production in the adaptation to metabolic disease

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To overcome these limitations, a Safety-by-Design approach has emerged