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However, the long-term treatment with GLP-1RAs may reduce the insulin levels in both T2DM (122) and prediabetic patients (123), owing to the glycemic normalization and increased insulin sensitivity in these patients

Activation of POMC neurons leads to the release of alpha-melanocyte-stimulating hormone (-MSH), which binds to melanocortin-4 receptors (MC4R) in downstream brain regions

Together, these findings suggested high public interest in GLP-1 RA and identified potential priorities for the clinical and policy communities, including monitoring side effects, addressing access barriers, and acknowledging both the physical and psychological benefits of GLP-1 RAs

Prospective study of gut hormone and metabolic changes after laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass

doi: 10.1016/j.eprac.2023.11.007 64 MoseleyKF