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Compounding pharmacies operate under state pharmacy boards and follow specific quality standards, though theyre not subject to the same FDA approval process as manufactured drugs

By mimicking the naturally occurring glucagon-like peptide-1 (GLP-1) hormone, semaglutide has been extensively studied for its effects on appetite regulation, glucose metabolism, insulin response, and overall metabolic function

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Maintaining adequate protein intake becomes particularly important during weight loss, as both fat and lean tissue can be lost

Semaglutide's evidence base is much newer and arguably more robust for the chronic weight-management context: STEP-1 (NEJM, 2021) showed mean ~15% body weight reduction at 68 weeks on semaglutide 2.4 mg weekly