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GLP-1 agonists may be used alone in patients intolerant of metformin or in combination with metformin, thiazolidinediones, and sulfonylureas (or in any combination thereof)

A narrative research review found early evidence that GLP-1 medications may improve some sperm measures or testosterone levels in men with obesity or metabolic hypogonadism (a condition that impacts hormone production)

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Clinical trials show average weight loss of 1522% of body weight at 68 weeks

The protocol must go through approval, review, and discussion before the study begins