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Its pathogenesis involves aging, obesity, joint injury, genetic predisposition, biomechanical imbalance, and lifestyle factors ( Recent research underscores the link between metabolic disorders, particularly obesity and diabetes, and KOA ( Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1 RAs), a novel class of antidiabetic agents acting on GLP-1 receptors, exert dual glycemic control and weight-loss effects via enhancing insulin secretion, appetite suppression, and delayed gastric emptying ( Among GLP-1 RAs, semaglutide and tirzepatide are primarily indicated for weight management, while dulaglutide is predominantly used for glycemic control and liraglutide for both indications