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Substituting the primary amide with a cyano group and methyl group significantly improved potency

[DOI] [PMC free article] [PubMed] [Google Scholar] [54].Kontermann RE, Strategies for extended serum half-life of protein therapeutics, Curr Opin Biotechnol, 22 (2011) 868876

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Januvia & Janumet Januvia and Janumet are prescription drugs that belong to a group of Type 2 diabetes drugs called DPP-4 inhibitors
