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Need or prefer in-person medical supervision: Some patients - particularly those with complex medical histories, multiple medications, or conditions requiring physical examination - may benefit more from working with an in-person obesity medicine specialist or endocrinologist

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Unlike medications that require precise timing around meals or sleep, retatrutide operates on a pharmacokinetic profile designed for once-weekly administration

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Semaglutide has a half-life of approximately one week, meaning it takes about five to six weeks for the drug to be completely eliminated from the body after discontinuation

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