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Phase 2 trials are designed to explore dose ranges, early efficacy signals, and safety patterns in selected groups
The risk is elevated compared to those not on the medication, but it's not a guarantee

Polymorphisms of GLP-1 receptor gene and response to GLP-1 analogue in patients with poorly controlled type 2 diabetes

GLP-1 will induce satiation in animals deprived of food when ghrelin is blocked before administration of GLP-1 (CC Ronveaux, G DeLartigue, and HE Raybould, unpublished results, 2014) and, we have preliminary evidence to suggest that ghrelin restricts GLP-1Rs on VANs to the cytoplasm and that CCK will move GLP-1Rs to the plasma membrane ( Figure 2 )
however, the review noted that most included studies focused on patients with diabetes rather than those with obesity