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Discuss pregnancy plans with your healthcare provider, as weight loss medications should be discontinued at least 2 months before a planned pregnancy

[3] [4] These combined effects lead to improved glycaemic control in people with type 2 diabetes and significant weight loss in those using it for obesity management

Design In the obesity trial, 338 participants (mean age 48 years, 48% women, mean BMI 37.3 kg/m 2 ) were randomised (2:1:1:1:1:2:2) to retatrutide 1 mg, 4 mg (titration), 4 mg (no titration), 8 mg (slow titration), 8 mg (fast titration), 12 mg or placebo over 48 weeks [45]

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The delayed gastric emptying effect is most pronounced right after initiation and after each dose escalation