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A large retrospective cohort study revealed that T2DM patients treated with GLP-1RAs exhibited a significantly reduced risk of developing dementia compared with those receiving other glucose-lowering therapies.126 In a clinical trial involving cognitively intact individuals aged 4570 years at risk for AD, liraglutide administration for 12 weeks enhanced intrinsic connectivity within the default mode network as measured by resting-state functional magnetic resonance imaging, although no significant cognitive improvements were observed during the study period.127 In patients with mild cognitive impairment and AD, an 18-month course of exenatide was well tolerated but did not yield significant changes in clinical or cognitive outcomes or in most neuroimaging or biomarker assessments, except for a reduction in plasma neuronal extracellular vesicle A42 levels, potentially reflecting systemic neuronal status

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Key topics included the effectiveness of oral semaglutide in clinical practice, the positioning of the agent to optimize the treatment benefits, the possibility to adopt flexibility in the administration schedule, critical issues encountered, the role of patient communication and information in the importance of dose escalation and management of adverse events

The report cites two specific reporting infractions, one for a patient who experienced a stroke and another for a patient who committed suicide

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