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Most patients notice meaningful appetite reduction within 1-2 weeks, but the strongest effects typically emerge around week 3-4 when steady-state medication levels are reached

It has been shown previously that 14% weight loss due to a very-low-energy diet (VLED) resulted in counter-regulatory changes in appetite-regulating hormones, including a significant increase in fasting levels of ghrelin and significant reductions in the fasting levels of leptin, GLP-1, peptide YY (PYY), cholecystokinin (CCK) and amylin 48

This is a significant opening for many Medicaid enrollees

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