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They lost about 8% of their body weight in 24 weeks.1 Individuals who gained back some weight after surgery lost almost 9% of their body weight after six months of taking liraglutide or semaglutide.2 People who had surgery and started gaining weight again lost about 10-15% of their weight after six months of taking semaglutide or tirzepatide.3 In summary, obesity is a complex disease that requires a variety of tools to manage it long-term

In this Review, Cowie and Fisher describe the additional mechanisms of benefit of SGLT2 inhibitors, unrelated to improved glycaemic control.

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Pramlintide, Acetate [Pro25, 28, 29]-Amylin(1-37), Amide, analogue of human hormone Amylin