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[DOI] [PubMed] 19.MarsoSP,DanielsGH,Brown-FrandsenKetal.Liraglutide and cardiovascular outcomes in type 2 diabetes.N Engl J Med.2016;375:31122

It is tempting to speculate that treatment of GLP-1 RAs might be combined with drugs targeting calcium clock dynamics or intracellular calcium levels, such as calcium channel blockers, or other downstream effectors, to prevent heart rate increases in patients receiving GLP-1 RAs where this may be considered beneficial

You get 90% of the weight loss efficacy of the 12mg dose but with noticeably fewer side effects during the challenging weeks 6-8 period

Additionally, GLP-1s can also induce nausea or vomiting

Across animal models, GLP-1 receptor agonists consistently improved functional outcomes and produced marked reductions in infarct volume compared with placebo