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CrossRef Managing metabolic diseases: The roles and therapeutic prospects of herb-derived polysaccharides Xinmei Xu, Lijie Wang, Kun Zhang, Yi Zhang, Gang Fan Biomedicine & Pharmacotherapy.2023

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Data summarised in the Xenical 120 mg SmPC and in Cochrane reviews indicate that, on average, orlistat 120 mg produces approximately 2.53.5 kg more weight loss than placebo over 12 months, with a greater proportion of patients achieving clinically meaningful thresholds of 5% or 10% body weight loss