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These findings align closely with prior cardiovascular outcome trials and solidify the evidence base by demonstrating consistent benefits in broader patient populations treated in clinical practice

In particular, the first study demonstrated that, along with improvements in anthropometric parameters, HOMA-IR reduced in both treatment arms, but liraglutide 1.2 mg/day was superior to metformin also in reducing glucose levels at 120 min during OGTT [57]

Most patients find that bowel changes are most noticeable during initial treatment and often improve as their body adapts to the medication, though some degree of altered bowel pattern may persist throughout treatment

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